• Biomaterials for Assay Calibrators, Controls & LC-MS/MS | Monobind
Focus Area

Biomaterials

Biological Matrices for Calibrators, Controls, Assay Development & LC-MS/MS

Human serum, plasma, urine, specialty matrices, protein materials, characterized patient specimens, and custom biomaterials for diagnostic, analytical, and method-development applications.

Matrix Selection Shapes the Whole Analytical Result

Biological matrices are more than a background — they carry proteins, lipids, salts, and endogenous compounds that can influence extraction recovery, ionization, calibration response, and analyte stability throughout an analytical method.

The most appropriate matrix depends on the intended specimen type, analyte concentration range, analytical platform, and development objective — which is why Monobind offers native, processed, and specialty low-analyte materials across serum, plasma, urine, and protein categories.

Key Biomaterial Considerations

Specimen Representativeness

How closely a material's biological characteristics match the intended patient or research specimen.

Endogenous Background

Naturally occurring analyte concentrations that can complicate calibration and control preparation.

Processing Effects

Stripping, delipidation, and other processing steps can alter matrix behavior beyond the target analyte.

Lot Consistency

Composition can vary lot to lot, which can affect long-term calibration and control stability.

Explore Biomaterial Families

Select biological materials according to specimen type, analyte profile, processing requirements, and intended application.

Matrix Processing Matters

Processing can selectively reduce endogenous components and alter the biological background of a matrix. The appropriate process depends on the analyte, specimen type, analytical method, and performance requirements.

Charcoal Stripping
Reduces steroid hormones and selected hydrophobic compounds.
Resin Stripping
Reduces thyroid hormones and selected endogenous components.
Delipidation
Reduces lipids and lipid-associated material.
Defibrination
Reduces fibrinogen and clot-forming material.

Residual concentrations vary by material, process, and lot. Lot-specific analytical information is provided where applicable, and custom materials can be developed to defined specifications.

Science & Application Guidance

Biomaterial Science, Assay & Application Development

From characterized patient specimens and custom biological materials to calibration matrices and LC-MS/MS method development, Monobind supports multiple stages of the analytical workflow.

Assay Development

Individual Patient Samples
Individual human serum or plasma specimens selected by characterized analyte concentration for assay design, feasibility, sensitivity evaluation, cutoff studies, and method optimization.
Targeted Concentration Samples
Source specimens around key analytical ranges or clinical decision points to support sensitivity, linearity, cutoff evaluation, and method development.
Custom Sample Sets
Configure panels around defined analytes, concentration ranges, specimen types, and assay-development requirements.

Custom Biomaterial Solutions

Materials Produced to Defined Specifications

Monobind can process, characterize, and formulate biological materials to customer-defined requirements, from development quantities through recurring bulk supply.

✓ Defined analyte profiles
✓ Target protein concentration
✓ Custom stripping or depletion
✓ Preservative systems
✓ pH and electrolyte targets
✓ Development & bulk quantities

Request a Biomaterial for Your Application

Tell us your material type, target analyte or specification, approximate volume, and application. Our team can help identify an appropriate human serum, plasma, urine, specialty matrix, protein material, or custom biomaterial for evaluation.